Good news for diabetics! A new drug approved Beovu (brolucizumab) by the FDA to treat diabetic macular edema in people with type 1 or type 2 diabetes. This medication may be able to protect you or someone you care about from diabetes-related vision loss.
One of the most common diabetes-related eye complications and causes of vision loss is diabetic macular edema (DME). DME affects approximately 12% of people with type 1 diabetes and 28% of people with type 2 diabetes. This condition is also one of the leading causes of blindness and vision loss in the world.
When blood vessels in the eyes become damaged, fluid begins to leak into the macula, a part of the retina responsible for a person’s most vivid, central vision. This buildup is frequently caused by the formation of new small blood vessels in the macula, which is triggered by the hormone VEGF. Beovu is a VEGF inhibitor, a type of medication that prevents the formation of new blood vessels in the macula and thus helps to prevent further fluid buildup.
Beovu was approved by the FDA in 2019 for another diabetes-related eye condition called age-related macular degeneration (AMD), which is another leading cause of blindness, prior to its new indication as a treatment for DME. In March 2022, the drug was also approved for DME in Europe.
Beovu’s approval for DME follows positive results from two phase 3 clinical trials, KESTREL and KITE. In these trials, Beovu was compared to Eylea, a similar eye medication that is currently the standard treatment for DME. When compared to the impact of Eylea, people taking Beovu had similar improvements in visual acuity (ability to distinguish shapes and objects) and reductions in fluid buildup.
Furthermore, while both drugs provided comparable overall improvements in vision, Beovu requires fewer doses to achieve the same effect. Both Beovu and Eylea are administered via eyeball injection, which necessitates a trip to the clinic. Participants in the KESTREL and KITE studies who received Eylea received one injection per month for the first five months, followed by injections every eight weeks. In comparison, Beovu participants received five injections six weeks apart, followed by injections every 12 weeks. While the frequency of this treatment varied depending on the needs of the individual, in both studies, more than half of Beovu participants maintained the 12-week intervals throughout the two-year study.
Following the approval of the new drug Vabysmo in February 2022, the approval of Beovu as a treatment for DME represents another advancement in the treatment options for diabetes-related eye diseases. Fewer injections could significantly reduce the burden of receiving eye treatments required to protect against vision loss. For people with DME, this means fewer clinic visits, fewer eye injections, and potentially lower treatment costs due to the need for fewer doses.
For more helpful eye care and vision care tips, please visit our main blog page.
Source: diatribe.org
Image by thatbaldguy from Pixabay
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There’s a ‘ghost hurricane’ in the forecast. It could help predict a real one
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A scary-looking weather forecast showing a hurricane hitting the Gulf Coast in the second half of June swirled around social media this week—but don’t panic.
It’s the season’s first “ghost hurricane.”
Similar hype plays out every hurricane season, especially at the beginning: A cherry-picked, worst-case-scenario model run goes viral, but more often than not, will never come to fruition.
Unofficially dubbed “ghost storms” or “ghost hurricanes,” these tropical systems regularly appear in weather models — computer simulations that help meteorologists forecast future conditions — but never seem to manifest in real life.
The model responsible this week was the Global Forecast System, also known as the GFS or American model, run by the National Oceanic and Atmospheric Administration. It’s one of many used by forecasters around the world.
All models have known biases or “quirks” where they tend to overpredict or underpredict certain things. The GFS is known to overpredict tropical storms and hurricanes in longer-term forecasts that look more than a week into the future, which leads to these false alarms. The GFS isn’t alone in this — all models struggle to accurately predict tropical activity that far in advance — but it is notorious for doing so.
For example, the GFS could spit out a prediction for a US hurricane landfall about 10 days from now, only to have that chance completely disappear as the forecast date draws closer. This can occur at any time of the year, but is most frequent during hurricane season — June through November.
It’s exactly what’s been happening over the past week as forecasters keep an eye out for the first storm of the 2025 Atlantic hurricane season.
Why so many ghosts?
No weather forecast model is designed in the exact same way as another, and that’s why each can generate different results with similar data.
The reason the GFS has more false alarms when looking more than a week out than similar models – like Europe’s ECMWF, Canada’s CMC or the United Kingdom’s UKM – is because that’s exactly what it’s programmed to do, according to Alicia Bentley, the global verification project lead of NOAA’s Environmental Modeling Center.
The GFS was built with a “weak parameterized cumulus convection scheme,” according to Bentley. In plain language, that means when the GFS thinks there could be thunderstorms developing in an area where tropical systems are possible – over the oceans – it’s more likely to jump to the conclusion that something tropical will develop than to ignore it.
Other models aren’t built to be quite as sensitive to this phenomenon, and so they don’t show a tropical system until they’re more confident the right conditions are in place, which usually happens when the forecast gets closer in time.
The western Caribbean Sea is one of the GFS’ favorite places to predict a ghost storm. That’s because of the Central American gyre: a large, disorganized area of showers and thunderstorms that rotates over the region and its surrounding water.
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