Genetic Target for Treating Blindness

Good News

Therapies developed for various forms of blindness are extremely challenging because they can vary so widely but Scientists from Trinity College in Dublin have highlighted a genetic target for treating blindness and a range of ocular conditions.

Their Scientist’s have highlighted a specific Gene (SARM1) as the key driver to the damage that will lead to impaired vision and sometimes blindness. Deleting this gene protects vision after a chemical kick-starts the chain of dysfunction that mimics a host of ocular conditions. Meaning that therapies targeting the suppression of SARM1 activity may hold the key to effective options for treating diseases that can have a devastating impact on quality of life, where currently no treatment options are available.

The Study

A team from Trinity’s School of Genetics and Microbiology have published their findings in the International Journal of Molecular Sciences. The first author, Laura Finnegan, PhD candidate, says

“In response to injury SARM1 contributes to a process that leads to the degeneration of specialised cells and their axons in the eye. When this happens it essentially means that the optic nerve can no longer deliver signals from the eye to the brain.

“Impaired vision and blindness is extremely debilitating for millions of people across the globe, which is one of the main motivations for us to seek to better understand the genetic causes and, potentially, develop life-changing therapies.”

Jane Farrar, Professor in Trinity’s School of Genetics and Microbiology, and senior author on the paper, said:

“Another important finding was that visual function was still preserved when reassessed four months after SARM1 was deleted, indicating that the benefits can remain over time. This raises hopes that a targeted therapy delivered early enough may offer people diagnosed with an ocular neuropathy long-lasting preservation of sight.

“We have a way to go before such a therapy is available but this work represents a significant step, sheds light on the pathway forward and offers hope that a range of diseases involving the optic nerve — from maternally inherited conditions such as Leber Hereditary Optic Neuropathy to the more commonly known glaucoma — will one day be treatable via such therapies.”

The research is the result of collaboration between Professor Farrar’s lab in the School of Genetics and Microbiology and that of Professor Andrew Bowie’s in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute. It was funded by the Irish Research Council, Science Foundation Ireland, the Health Research Board of Ireland and Fighting Blindness Ireland.